The TOPAZ Trial is recruiting adults with OI in UK, Ireland, Netherlands, France and Denmark. The trial is designed to determine if anabolic therapy with Teriparatide (TPTD) followed by a single infusion of zoledronic acid (ZA) is superior to standard care in adults with OI. The trial is open to anyone over 18 years with OI whether or not they have previously been treated. The only exception is people who have received anabolic therapies in the past two years.

If you are interested in taking part in the study please feel free to email the study team on or Professor Stuart H Ralston, the Chief Investigator on for further information.

Read more about the trial in OIFE Magazine.